Polyherbal Extracts and Hormonal Crosstalk in Male and Female Fertility: Advances in Natural Endocrine Modulation

Omutindo Nyakayo A.

Faculty of Science and Technology Kampala International University Uganda

ABSTRACT

Hormonal balance plays a pivotal role in regulating fertility in both sexes, orchestrated through intricate crosstalk between hypothalamic, pituitary, and gonadal hormones. Dysregulation in this hormonal network underlies many reproductive disorders, including polycystic ovary syndrome (PCOS), hypogonadism, infertility, and irregular menstrual cycles. While conventional hormonal therapies offer targeted intervention, they are often accompanied by side effects and long-term safety concerns. Increasingly, attention is turning to polyherbal extract combinations of multiple medicinal plants known for their synergistic and multifaceted biological actions. This review explores how polyherbal formulations interact with endocrine systems to modulate hormonal crosstalk, restore fertility, and improve reproductive outcomes. Drawing from evidence in traditional medicine, animal studies, and emerging clinical trials, we examine the mechanisms of endocrine modulation, including hypothalamic-pituitary axis stimulation, steroidogenic pathway regulation, antioxidant defense enhancement, and receptor-level interactions. Additionally, we discuss bioavailability challenges, safety concerns, and regulatory perspectives. The review advocates for an integrative, evidence-based approach to using polyherbal therapies in reproductive medicine.

Keywords: Polyherbal Extracts, Fertility, Hormonal Crosstalk, Endocrine Modulation, Reproductive Health

CITE AS: Omutindo Nyakayo A. (2025). Polyherbal Extracts and Hormonal Crosstalk in Male and Female Fertility: Advances in Natural Endocrine Modulation. RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES 4(3):83-87. https://doi.org/10.59298/RIJRMS/2025/438387