Lipid-Based Nanocarriers for Dual Modulation of Lipid Metabolism and Glucose Homeostasis

Wotsomu Evasi

Clinical Pharmacology and Antimicrobial resistance Kampala International University Uganda

Email: evasi.wotsomu@stdwc.kiu.ac.ug

ABSTRACT

Lipid metabolism and glucose homeostasis are two intertwined metabolic processes that are often dysregulated in conditions such as obesity, insulin resistance, and type 2 diabetes (T2D). Given the complexity of these disorders, therapeutic strategies targeting both lipid and glucose metabolism are critical for effective management. Lipid-based nanocarriers, including liposomes, solid lipid nanoparticles (SLNs), and nanostructured lipid carriers (NLCs), offer promising platforms for the dual modulation of lipid metabolism and glucose homeostasis. These nanocarriers can encapsulate bioactive compounds that regulate lipid and glucose pathways, provide targeted delivery to specific tissues, and enhance the bioavailability and therapeutic effects of drugs. This review explores the role of lipid-based nanocarriers in the dual modulation of lipid metabolism and glucose homeostasis, highlighting their mechanisms of action, therapeutic applications, and the challenges associated with their development and clinical translation.

Keywords: lipid metabolism, glucose homeostasis, nanocarriers, liposomes, insulin resistance, type 2 diabetes

CITE AS: Bwambale Isaac (2026). Lipid-Based Nanocarriers for Dual Modulation of Lipid Metabolism and Glucose Homeostasis. RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES 5(1):18-23. https://doi.org/10.59298/RIJRMS/2026/511823