Interplay between Liver, Kidney, and Heart in Metabolic Regulation and Cardioprotection: Mechanisms and Implications for Therapeutic Strategies

Tom Akello Abbo

Department of Pharmacology, Kampala International University Uganda

ABSTRACT

The intricate interplay between the liver, kidney, and heart in metabolic regulation and cardioprotection is a topic of growing interest, particularly in the context of rising cardiovascular disease prevalence. This paper explores the dynamic interactions among these organs, highlighting their roles in energy metabolism, inflammation, and cardiovascular health. We discuss the mechanisms through which liver and kidney function impact cardioprotective properties, including the regulation of glucose and lipid metabolism, inflammation modulation, and remote conditioning effects. Furthermore, we examine the implications of liver-kidney-heart cross-talk for therapeutic strategies targeting cardiometabolic disorders. Understanding these complex interactions is essential for the development of innovative treatments to mitigate the burden of cardiovascular disease.

Keywords: Liver, Kidney, Heart, Cardioprotection and Therapy

CITE AS: Tom Akello Abbo (2024). Interplay between Liver, Kidney, and Heart in Metabolic Regulation and Cardioprotection: Mechanisms and Implications for Therapeutic Strategies. RESEARCH INVENTION JOURNAL OF PUBLIC HEALTH AND PHARMACY 3(1): 1-8