Attenuating Bacterial Virulence through Natural Product-Derived Peptidomimetics: A Novel Approach to Combatting Multidrug-Resistant Infections
1Ugwu Okechukwu Paul-Chima, 2Alum Esther Ugo and 3Uhama Kingsley Chukwuka
1,2Department of Publication and Extension Kampala International University Uganda
3Department of Biochemistry, Faculty of Applied Natural Sciences, Enugu State University of Science and Technology, Nigeria.
ABSTRACT
In the fight against multidrug-resistant (MDR) bacterial infections, traditional antibiotic approaches are increasingly proving ineffective due to the rapid development of resistance. An innovative strategy focuses on attenuating bacterial virulence rather than killing the bacteria, reducing the pressure for resistance development. This study investigates the potential of natural product-derived peptidomimetics to inhibit bacterial virulence factors, thereby neutralizing pathogenicity and allowing the host immune system to eradicate the non-virulent bacteria. By leveraging the unique properties of these compounds, which have evolved to protect natural producers from environmental threats, we aim to design peptidomimetics that selectively interfere with bacterial virulence mechanisms. This approach promises a sustainable and effective solution to the global challenge of antibiotic resistance.
Keywords: Bacterial virulence, Multidrug resistance, Peptidomimetics, Natural products and Antimicrobial resistance.
CITE AS: Ugwu Okechukwu Paul-Chima, Alum Esther Ugo and Uhama Kingsley Chukwuka (2024). Attenuating Bacterial Virulence through Natural Product-Derived Peptidomimetics: A Novel Approach to Combatting Multidrug-Resistant Infections. RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES 3(2):1-5.