Understanding the Role of Gut Microbiota-Derived Metabolites in Modulating Immune Responses

Okafor, Azubuike Ikechukwu

Department of Medical Biochemistry, University of Cross River State, Calabar, Nigeria

Email: okafor.azubuike@gmail.com; phone number: +2348035723454

                                                                            ABSTRACT
Gut microbiota-derived metabolites play a critical role in modulating immune responses, impacting both local mucosal and systemic immunity. The complex interactions between the host immune system and microbial metabolites have evolved to maintain homeostasis and protect against pathogens. Dysbiosis, or disruption of the gut microbiota, is linked to various non-communicable diseases, such as diabetes, obesity, and cancer, often through immune dysregulation. This review explores the composition of gut microbiota, the metabolites they produce, and their impact on immune cells, including T cells, dendritic cells, and B cells. The clinical implications of these interactions are discussed, highlighting the potential for personalized therapies targeting gut microbiota-derived metabolites to treat immune-related diseases.

Keywords: Gut microbiota, metabolites, immune responses, dysbiosis, non-communicable diseases.

CITE AS: Okafor, Azubuike Ikechukwu. Understanding the Role of Gut Microbiota-Derived Metabolites in Modulating Immune Responses. RESEARCH INVENTION JOURNAL OF BIOLOGICAL AND APPLIED SCIENCES, 2023 2(1):6-9.