Phytochemicals and Vitamins as Adjunct Therapies for Diarrhea in Diabetic Patients

¹Ugwu Okechukwu Paul-Chima, ²Alum Esther Ugo and ³Uhama Kingsley Chukwuka

^1,2Department of Publication and Extension Kampala International University Uganda

³Department of Biochemistry, Faculty of Applied Natural Sciences, Enugu State University of Science and Technology, Nigeria.                   

ABSTRACT

Diarrhea is a common and challenging complication in diabetic patients, exacerbated by anti-diabetic medications such as metformin. This condition severely impacts patients’ quality of life and can lead to serious complications, including dehydration and malnutrition. This review examines the potential of phytochemicals and vitamins as adjunct therapies for managing diarrhea in diabetic patients. We explore the mechanisms by which these natural compounds mitigate diarrhea, focusing on their anti-inflammatory, antioxidant, and anti-apoptotic properties. Specifically, the review highlights the roles of vitamins such as biotin, niacin, and vitamin K, and phytochemicals including carotenoids, lutein, and zeaxanthin. Clinical evidence suggests these compounds can improve intestinal function, enhance glucose absorption, and reduce oxidative stress, providing a multifaceted approach to managing diabetic diarrhea. Further clinical studies are necessary to confirm these benefits and optimize therapeutic strategies.

Keywords: Diabetic diarrhea, phytochemicals, vitamins, adjunct therapy, oxidative stress and inflammation

CITE AS: Ugwu Okechukwu Paul-Chima, Alum Esther Ugo and Uhama Kingsley Chukwuka (2024). Phytochemicals and Vitamins as Adjunct Therapies for Diarrhea in Diabetic Patients. RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES 3(2):27-37.