Interconnection between Depressive Disorders and Persistent Diseases

Adroa Afiya B.

Faculty of Clinical Medicine and Dentistry Kampala International University Teaching Hospital Western Campus Uganda.

ABSTRACT

The interconnection between depressive disorders and persistent diseases reveals intricate biological, psychological, and behavioral mechanisms that exacerbate both conditions. Chronic inflammation, hormonal imbalances, neurotransmitter dysfunction, oxidative stress, and gut microbiota dysbiosis are key biological pathways linking depression with chronic illnesses such as cardiovascular disease, diabetes, and autoimmune disorders. Psychologically, chronic stress, negative thinking patterns, and emotional distress contribute to the onset and progression of both depressive disorders and persistent diseases. Behaviorally, poor diet, sedentary lifestyle, substance abuse, and non-adherence to medical treatments further compound health outcomes. Addressing this comorbidity is crucial for effective disease management, healthcare utilization, and overall public health. Integrated care models and multidisciplinary interventions can improve treatment adherence, self-care behaviors, and quality of life, while public health initiatives aimed at mental health promotion and early intervention can mitigate the burden of these conditions.

Keywords: Depressive Disorders, Persistent Diseases, Chronic Inflammation, Neurotransmitter Dysfunction, Chronic Stress, Behavioral Patterns, Integrated Care

CITE AS: Adroa Afiya B. (2024). Interconnection between Depressive Disorders and Persistent Diseases. RESEARCH INVENTION JOURNAL OF RESEARCH IN MEDICAL SCIENCES 3(1):45-51.